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ANDI(1) andi manual ANDI(1) NAME andi - estimates evolutionary distances SYNOPSIS andi [OPTIONS...] FILES... DESCRIPTION andi estimates the evolutionary distance between closely related genomes. For this andi reads the input sequences from FASTA files and computes the pairwise anchor distance. The idea behind this is ex- plained in a paper by Haubold et al. (2015). OUTPUT The output is a symmetrical distance matrix in PHYLIP format, with each entry representing divergence with a positive real number. A distance of zero means that two sequences are identical, whereas other values are estimates for the nucleotide substitution rate (Jukes-Cantor cor- rected). For technical reasons the comparison might fail and no esti- mate can be computed. In such cases nan is printed. This either means that the input sequences were too short (<200bp) or too diverse (K>0.5) for our method to work properly. OPTIONS -b INT, --bootstrap=INT Compute multiple distance matrices, with n-1 bootstrapped from the first. See the paper Kltzl & Haubold (2016) for a detailed explanation. --file-of-filenames=FILE Usually, andi is called with the filenames as commandline argu- ments. With this option the filenames may also be read from a file itself, with one name per line. Use a single dash ('-') to read from stdin. -j, --join Use this mode if each of your FASTA files represents one assem- bly with numerous contigs. andi will then treat all of the con- tained sequences per file as a single genome. In this mode at least one filename must be provided via command line arguments. For the output the filename is used to identify each sequence. -l, --low-memory In multithreaded mode, andi requires memory linear to the amount of threads. The low memory mode changes this to a constant de- mand independent from the used number of threads. Unfortunately, this comes at a significant runtime cost. -m MODEL, --model=MODEL Set the nucleotide evolution model to one of 'Raw', 'JC', 'Kimura', or 'LogDet'. By default the Jukes-Cantor correction is used. -p FLOAT Significance of an anchor; default: 0.025. --progress[=WHEN] Print a progress bar. WHEN can be 'auto' (default if omitted), 'always', or 'never'. -t INT, --threads=INT The number of threads to be used; by default, all available processors are used. Multithreading is only available if andi was compiled with OpenMP support. --truncate-names By default andi outputs the full names of sequences, optionally padded with spaces, if they are shorter than ten characters. Names longer than ten characters may lead to problems with down- stream tools. With this switch names will be truncated. -v, --verbose Prints additional information, including the amount of found ho- mology. Apply multiple times for extra verboseness. -h, --help Prints the synopsis and an explanation of available options. --version Outputs version information and acknowledgments. COPYRIGHT Copyright (C) 2014 - 2021 Fabian Kltzl License GPLv3+: GNU GPL version 3 or later. This is free software: you are free to change and redistribute it. There is NO WARRANTY, to the extent permitted by law. The full license text is available at <http://gnu.org/licenses/gpl.html>. ACKNOWLEDGMENTS 1) andi: Haubold, B. Kltzl, F. and Pfaffelhuber, P. (2015). andi: Fast and accurate estimation of evolutionary distances between closely re- lated genomes, Bioinformatics 31.8. 2) Algorithms: Ohlebusch, E. (2013). Bioinformatics Algorithms. Se- quence Analysis, Genome Rearrangements, and Phylogenetic Reconstruc- tion. pp 118f. 3) SA construction: Mori, Y. (2005). libdivsufsort, unpublished. 4) Bootstrapping: Kltzl, F. and Haubold, B. (2016). Support Values for Genome Phylogenies, Life 6.1. BUGS Reporting Bugs Please report bugs to <kloetzl@evolbio.mpg.de> or at <https://github.com/EvolBioInf/andi>. 0.15-beta 2020-01-09 ANDI(1)
NAME | SYNOPSIS | DESCRIPTION | OUTPUT | OPTIONS | COPYRIGHT | ACKNOWLEDGMENTS | BUGS
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